p53 Targeting Can Enhance Cancer Therapy via Radiation, Heat and Anti-Cancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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p53 Targeting Can Enhance Cancer Therapy via Radiation, Heat and Anti-Cancer Agents



Anti-Cancer Agents in Medicinal Chemistry, 8(5): 564-570.

Author(s): Takeo Ohnishi, Akihisa Takahashi, Eiichiro Mori and Ken Ohnishi.

Affiliation: Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

Abstract

In recent years, genes associated with cancer have been studied to assess their possible use as predictive indicators for cancer therapies. Among these, the gene product of the tumor suppressor gene p53 was found to play an important role in cancer therapy. The p53 molecule induces cell-cycle arrest, apoptosis and DNA repair after cells are subjected to cancer therapies involving radiation, heat and various anti-cancer agents. Mutations in p53 are observed at a high frequency in human tumors, and are present in about half of all malignant tumors in humans. Sensitization to radiation, heat and anti-cancer agents was observed in cells containing wild type p53, but not in cells containing mutated p53. This review discusses p53 activation of signaling pathways after exposure to cancer therapies which target p53; such therapies include chemical chaperones, the p53 gene, p53-C terminal peptides, and p53-targeting agents which enhance p53-central signal transduction pathways.

Keywords:

p53, chemical chaperones, apoptosis, radiation, heat.



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Article Details

Volume: 8
Issue Number: 5
First Page: 564
Last Page: 570
Page Count: 7
DOI: 10.2174/187152008784533017
Price: $58
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