Novel Molecular-Targeted Therapeutics for the Treatment of Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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5 - Year: 2.849

Novel Molecular-Targeted Therapeutics for the Treatment of Cancer

Anti-Cancer Agents in Medicinal Chemistry, 8(5): 470-480.

Author(s): Hiroshi Yasui and Kohzoh Imai.

Affiliation: Sapporo Medical University,South 1, West 17, Chuo-ku, Sapporo, 060-0061, Japan.


Recently, intensive laboratory and preclinical studies have identified and validated therapeutic molecular targets in cancer, particularly the receptor tyrosine kinases, the intracellular pathways, and the genetic and epigenetic alterations, resulting in an unprecedented surge of novel, targeted therapies and therapeutic regimens. There are currently over 30 new agents being tested in the treatment of solid tumors as well as hematologic malignancies. Many of these are novel, targeted agents that have demonstrated significant efficacy and prolonged survival. Here, we discuss the current understanding of the mechanisms of action of novel molecular targeted cancer therapies being tested in the preclinical and clinical settings, including agents that act directly on the cell surface receptors, intracellular signaling pathways, and cell maintenance processes.


Small molecule inhibitor, monoclonal antibody, antisense oligonucleotide, ell surface receptors, receptor tyrosine kinase, the intracellular pathway.

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Article Details

Volume: 8
Issue Number: 5
First Page: 470
Last Page: 480
Page Count: 11
DOI: 10.2174/187152008784533099
Price: $58
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