BRCA-FA Pathway as a Target for Anti-Tumor Drugs

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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BRCA-FA Pathway as a Target for Anti-Tumor Drugs



Anti-Cancer Agents in Medicinal Chemistry, 8(4): 426-430.

Author(s): Rachel Litman, Rigu Gupta, Robert M. Brosh, Jr. and Sharon B Cantor.

Affiliation: Department of Cancer Biology,UMASS Medical School, 364 Plantation St., Worcester, MA 01605,USA.

Abstract

Promising research on DNA repair signaling pathways predicts a new age of anti-tumor drugs. This research was initiated through the discovery and characterization of proteins that functioned together in signaling pathways to sense, respond, and repair DNA damage. It was realized that tumor cells often lacked distinct DNA repair pathways, but simultaneously relied heavily on compensating pathways. More recently, researchers have begun to manipulate these compensating pathways to reign in and kill tumor cells. In a striking example it was shown that tumors derived from mutations in the DNA repair genes, of BRCA-FA pathway, were selectively sensitive to inhibition of the base excision repair pathway. These findings suggest that tumors derived from defects in DNA repair genes will be easier to treat clinically, providing a streamlined and targeted therapy that spares healthy cells. In the future, identifying patients with susceptible tumors and discovering additional DNA repair targets amenable to anti-tumor drugs will have a major impact on the course of cancer treatment.

Keywords:

Fanconi anemia, DNA repair, anti-tumor drug, BRCA.



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Article Details

Volume: 8
Issue Number: 4
First Page: 426
Last Page: 430
Page Count: 5
DOI: 10.2174/187152008784220285
Price: $58
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