Cancer Chemoprevention by Garlic and Its Organosulfur Compounds-Panacea or Promise?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Cancer Chemoprevention by Garlic and Its Organosulfur Compounds-Panacea or Promise?



Anti-Cancer Agents in Medicinal Chemistry, 8(3): 313-321.

Author(s): Siddavaram Nagini.

Affiliation: Department of Biochemistry and Biotechnology Faculty of Science, Annamalai University Annamalainagar-608 002 Tamil Nadu, India.

Abstract

Of late medicinal plants and functional foods rich in bioactive phytochemicals have received growing attention as potential agents for cancer chemoprevention. Accumulating evidence from epidemiological studies as well as laboratory data supports the anticancer properties of garlic widely used as a medicinal herb and spice. Garlic and its organosulfur compounds (OSCs) appear to exert their anticarcinogenic effects through multiple mechanisms that include modulation of carcinogen metabolism, inhibition of DNA adduct formation, upregulation of antioxidant defences and DNA repair systems, and suppression of cell proliferation by blocking cell cycle progression and/or inducing apoptosis. Since multiple signaling pathways are dysfunctional in cancer and new oncogenic mutations accumulate with carcinogenic progression, dietary agents such as garlic with its rich array of bioactive OSCs that modulate cancer cascades offer promise as potential chemopreventive and chemotherapeutic agents.

Keywords:

Apoptosis, cancer, cell cycle, garlic, organosulfur compounds.



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Article Details

Volume: 8
Issue Number: 3
First Page: 313
Last Page: 321
Page Count: 9
DOI: 10.2174/187152008783961879
Price: $58
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