Biological and Pharmacological Roles of N6-Isopentenyladenosine: An Emerging Anticancer Drug

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Biological and Pharmacological Roles of N6-Isopentenyladenosine: An Emerging Anticancer Drug



Anti-Cancer Agents in Medicinal Chemistry, 8(2): 200-204.

Author(s): Maurizio Bifulco, Anna Maria Malfitano, Maria Chiara Proto, Antonietta Santoro, Maria Gabriella Caruso and Chiara Laezza.

Affiliation: Dipartmento di Scienze Farmaceutiche,Universitadi Salerno, 84084 Fisciano (SA).

Abstract

A common modification of eukaryotic and bacterial tRNAs is isopentenylation of the adenosine at position 37, with the formation of isopentenyladenosine. N6-Isopentenyladenosine plays a major role in posttranscriptional processes, including the function of mammalian selenocysteine tRNA. This molecule seems to have metabolic effects that, for its relationships with isoprenoid metabolism and its direct biological activities, affects mammalian cell cytoskeleton, proliferation and apoptosis. In addition, preliminary clinical observation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug.

Keywords:

N6-Isopentenyladenosine, apoptosis, cancer.



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Article Details

Volume: 8
Issue Number: 2
First Page: 200
Last Page: 204
Page Count: 5
DOI: 10.2174/187152008783497028
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