Acetylenic Anticancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Acetylenic Anticancer Agents

Anti-Cancer Agents in Medicinal Chemistry, 8(2): 132-170.

Author(s): A. Siddiq and V Dembitsky.

Affiliation: Department of Pharmacology,Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan.


This review is a comprehensive survey of acetylenic anticancer agents obtained from living organisms. Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. Although acetylenes are common as components of terrestrial plants, fungi, and bacteria, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from plants, cyanobacteria, algae, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifungal, phototoxic, HIV inhibitory, and immunosuppressive properties. There is no doubt that they are of great interest, especially for the medicinal chemistry, and/or pharmaceutical industries. This review presents structures and describes cytotoxic activities of more than 300 acetylenic metabolites isolated from living organisms.


Acetylenic, polyacetylenes, antitumor, agents, cytotoxic, bacteria, cyanobacteria, algae, invertebrates, fungi.

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Article Details

Volume: 8
Issue Number: 2
First Page: 132
Last Page: 170
Page Count: 39
DOI: 10.2174/187152008783497073
Price: $58
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