Altered Glycosylation of Proteins in Cancer: What Is the Potential for New Anti-Tumour Strategies

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Altered Glycosylation of Proteins in Cancer: What Is the Potential for New Anti-Tumour Strategies

Anti-Cancer Agents in Medicinal Chemistry, 8(1): 2-21.

Author(s): S. A. Brooks, T. M. Carter, L. Royle, D. J. Harvey, S. A. Fry, C. Kinch, R. A. Dwek and P M Rudd.

Affiliation: School of Biological&Molecular Sciences, Oxford Brookes University, Gipsy Lane, Headington,Oxford,OX3 0BP, UK.


It is becoming increasingly apparent that cell surface oligosaccharides play pivotal roles as recognition molecules in a range of cell communication and adhesion processes. Alterations in cellular glycosylation are also associated with diseases, including cancer, and may have functional significance. This paper gives an overview of the complex topic of cellular glycosylation mechanisms and reviews the well-documented alterations in cellular glycosylation of proteins in malignancy. One particular type of cancer-associated glycosylation change, the incomplete synthesis of O-linked glycans, is highlighted, and its possible functional significance in cancer cell metastatic mechanisms is discussed. The significance that cancer-associated changes in glycoprotein glycosylation may have in new approaches to anti-tumour therapies is explored.


Glycoprotein, glycosylation, glycan analysis, cancer, metastasis, Helix pomatia agglutinin, HPA.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 8
Issue Number: 1
First Page: 2
Last Page: 21
Page Count: 20
DOI: 10.2174/187152008783330860
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science