Altered Glycosylation of Proteins in Cancer: What Is the Potential for New Anti-Tumour Strategies

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Altered Glycosylation of Proteins in Cancer: What Is the Potential for New Anti-Tumour Strategies



Anti-Cancer Agents in Medicinal Chemistry, 8(1): 2-21.

Author(s): S. A. Brooks, T. M. Carter, L. Royle, D. J. Harvey, S. A. Fry, C. Kinch, R. A. Dwek and P M Rudd.

Affiliation: School of Biological&Molecular Sciences, Oxford Brookes University, Gipsy Lane, Headington,Oxford,OX3 0BP, UK.

Abstract

It is becoming increasingly apparent that cell surface oligosaccharides play pivotal roles as recognition molecules in a range of cell communication and adhesion processes. Alterations in cellular glycosylation are also associated with diseases, including cancer, and may have functional significance. This paper gives an overview of the complex topic of cellular glycosylation mechanisms and reviews the well-documented alterations in cellular glycosylation of proteins in malignancy. One particular type of cancer-associated glycosylation change, the incomplete synthesis of O-linked glycans, is highlighted, and its possible functional significance in cancer cell metastatic mechanisms is discussed. The significance that cancer-associated changes in glycoprotein glycosylation may have in new approaches to anti-tumour therapies is explored.

Keywords:

Glycoprotein, glycosylation, glycan analysis, cancer, metastasis, Helix pomatia agglutinin, HPA.



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Article Details

Volume: 8
Issue Number: 1
First Page: 2
Last Page: 21
Page Count: 20
DOI: 10.2174/187152008783330860
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