Role of Focal Adhesion Kinase in Human Cancer: A Potential Target for Drug Discovery

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Role of Focal Adhesion Kinase in Human Cancer: A Potential Target for Drug Discovery



Anti-Cancer Agents in Medicinal Chemistry, 7(6): 681-684.

Author(s): Edward Kyu-Ho Han and Thomas McGonigal.

Affiliation: Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Research, Dept. R47S, Bldg.AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA.

Abstract

The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes to the points of cell contact with the extracellular matrix, called focal adhesions. FAK is involved in several cellular processes including invasion, motility, proliferation and apoptosis. In in vivo animal studies, FAK has been shown to contribute to tumor development and malignancy. Furthermore, FAK expression was shown to be elevated in a number of human cancers. Increased FAK expression and activity are correlated with malignant phenotype and poor prognosis in patients. Taken together, these studies suggest that FAK is a potentially good target for drug discovery. In this review, FAK and its relationship to cancer, as well as approaches to therapeutic intervention of FAK will be discussed.

Keywords:

Focal adhesion kinase (FAK), tumor, siRNA, small molecule inhibitors, FAK expression.



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Article Details

Volume: 7
Issue Number: 6
First Page: 681
Last Page: 684
Page Count: 4
DOI: 10.2174/187152007784111296
Price: $58
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