Searching for the Magic Bullet: Anticancer Platinum Drugs Which Can Be Accumulated or Activated in the Tumor Tissue

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Searching for the Magic Bullet: Anticancer Platinum Drugs Which Can Be Accumulated or Activated in the Tumor Tissue



Anti-Cancer Agents in Medicinal Chemistry, 7(1): 55-73.

Author(s): Markus Galanski and Bernhard K Keppler.

Affiliation: Institute of Inorganic Chemistry,University of Vienna, Waehringer Strasse 42, A-1090 Vienna, Austria.

Abstract

Cisplatin, carboplatin and oxaliplatin are anticancer drugs, which are efficiently used in the clinics all over the world. Besides a remarkable therapeutic efficacy in a series of solid tumors and outstanding activity of cisplatin against testicular germ-cell cancer, the platinum-based therapy is in part accompanied by a set of severe toxic side-effects. The design of platinum complexes being equipped with an exclusive selectivity for the tumoral tissue and exhibiting a lack of systemic toxicity (‘magic bullets’) is the great hope in the fight against cancer and also a motor within the expanding field of bioinorganic chemistry. In this review article, two promising strategies, namely accumulation and activation of tumor inhibiting platinum complexes specifically at the tumor site is presented, demonstrating a stepwise approach towards the ‘magic bullet’ concept propagated by Paul Ehrlich.

Keywords:

Platinum complexes, anticancer activity, mechanism of action, structure-activity relationships, synthesis, medicinal chemistry, accumulation, activation.



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Article Details

Volume: 7
Issue Number: 1
First Page: 55
Last Page: 73
Page Count: 19
DOI: 10.2174/187152007779314017
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