Stimuli-Sensitive Polymeric Micelles as Anticancer Drug Carriers

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Stimuli-Sensitive Polymeric Micelles as Anticancer Drug Carriers



Anti-Cancer Agents in Medicinal Chemistry, 6(6): 525-535.

Author(s): Kun Na, Vijay T. Sethuraman, You Han Bae and Vijay A Sethuraman.

Affiliation: Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 421 Wakara Way, Suite 318, Salt Lake City, Utah 84108, USA., Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 421 Wakara Way, Suite 318, Salt Lake City, Utah 84108, USA.

Abstract

Amphiphilic block copolymers often form core-shell type micelles by self-organization of the blocks in an aqueous medium or under specific experimental conditions. Polymeric micelles constructed from these polymers that contain a segment whose physical or chemical properties respond to small changes in environmental conditions are collectively called ‘stimuli-sensitive ’ micelles. This class of nano-scaled constructs has been investigated as a promising anticancer drug carrier because the micelles are able to utilize small environmental changes and modify drug release kinetics, biodistribution and the interactions with tissues and cells. This review summarizes the recent progress in stimuli-sensitive micelles for tumor chemotherapy, particularly for those responding to hyperthermic conditions, tumor pH and endosomal/ lysosomal pH.

Keywords:

Micelles, self-organization, stimuli-sensitive, hyperthermic conditions, tumor pH, endosomal/lysosomal pH.



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Article Details

Volume: 6
Issue Number: 6
First Page: 525
Last Page: 535
Page Count: 11
DOI: 10.2174/187152006778699068
Price: $58
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