Cytotoxic Molecules from Natural Sources: Tapping the Brazilian Biodiversity

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Cytotoxic Molecules from Natural Sources: Tapping the Brazilian Biodiversity

Anti-Cancer Agents in Medicinal Chemistry, 6(4): 367-375.

Author(s): Ivana Barbosa Suffredini, Antonio Drauzio Varella and Riad Naim Younes.

Affiliation: Laboratorio de Extracao - Uiversidade Paulista, Av. Paulista, 900, 1 andar, Sao Paulo, SP, Brazil, 01310-100.


The use of plant miscellaneous preparations as an alternative to the treatment of cancer is a reality today due to the massive marketing of natural medicines versus anticancer chemotherapy. Although this situation is controversial and has not led to any significant benefits to patients, plants may play a significant role in the treatment of cancer. Historically, natural leads have evolved to some of the outstanding medicines used nowadays against lung, breast, and ovarian cancers, and leukemia. Natural products are still some of the important sources of new anticancer drugs. The Brazilian flora is considered one of the most diverse in the world, although not many large-scale pharmacological and phytochemical studies have been conducted so far. We present the updated status and results of the research developed by Brazilian research centers on anticancer active substances derived from natural sources, mainly plants from the Brazilian Rain Forests, focusing on their potential effectiveness and difficulties.


biodiversity, screening, natural products, Amazon Rain Forest, Atlantic Forest.

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Article Details

Volume: 6
Issue Number: 4
First Page: 367
Last Page: 375
Page Count: 9
DOI: 10.2174/187152006777698187
Price: $58

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