A Computational View of COX-2 Inhibition

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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A Computational View of COX-2 Inhibition

Anti-Cancer Agents in Medicinal Chemistry, 6(3): 239-249.

Author(s): Philippe Chavatte and Amaury Farce.

Affiliation: Laboratoire de Chimie Therapeutique,EA1043, Faculte des Sciences Pharmaceutiques et Biologiques,BP 83, F-59006 Lille, France.


Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.


COX-1 enzyme, Diarylheterocycles, COX-2 isoenzymes, nimesulide, QSAR studies, Neural Networks.

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Article Details

Volume: 6
Issue Number: 3
First Page: 239
Last Page: 249
Page Count: 11
DOI: 10.2174/187152006776930909
Price: $58

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