The Use of Nimesulide and Its Analogues in Cancer Chemoprevention

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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The Use of Nimesulide and Its Analogues in Cancer Chemoprevention

Anti-Cancer Agents in Medicinal Chemistry, 6(3): 233-237.

Author(s): Jean-Francois Renard, Fabien Julemont, Xavier d. Leval and Bernard Pirotte.

Affiliation: Laboratoire de Chimiepharmaceutique, Natural and Synthetic Drugs Research Center, Universitede Liege, 1, Avenue de l'Hopital, Sart Tilman, B-4000 Liege, Belgium.


Non-steroidal anti-inflammatory drugs (NSAIDs), which are known to be cyclooxygenase (COX) inhibitors, have been reported to exert anti-proliferative and pro-apoptotic effects on a variety of cancer cells. Since the COX-2 isoform was found to be overexpressed in a many human cancers, a particular attention was paid on the possible use of selective COX-2 inhibitors in cancer chemoprevention. The present review focuses on the state of the art in cancer research developed with COX-2 preferential/selective inhibitors belonging to the family of N-arylmethanesulfonamides, in particular nimesulide and NS-398.


Nimesulide, NS-398, cancer chemoprevention, NSAIDs, cyclooxygenase inhibitors, anti-proliferative, proapoptotic, N-arylmethanesulfonamides.

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Article Details

Volume: 6
Issue Number: 3
First Page: 233
Last Page: 237
Page Count: 5
DOI: 10.2174/187152006776930855
Price: $58
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