Polyhedral Boron Compounds as Potential Diagnostic and Therapeutic Antitumor Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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Polyhedral Boron Compounds as Potential Diagnostic and Therapeutic Antitumor Agents



Anti-Cancer Agents in Medicinal Chemistry, 6(2): 75-109.

Author(s): V. I. Bregadze, I. B. Sivaev and S A Glazun.

Affiliation: A.N.Nesmeyanov Institute ofOrganoelement Compounds, Moscow, Russia.

Abstract

The use of polyhedral boron hydrides for cancer treatment is traditionally connected with boron neutron capture therapy. More recently, polyhedral borate anions were proposed as carriers of radionuclide label for targeted radionuclide therapy and diagnostics of cancer. Some metal derivatives of carboranes were found to demonstrate significant antitumor activity themselves. This review is designed to highlight the recent work concerning various fields of potential application of polyhedral boron compounds in anticancer diagnostics and therapy.

Keywords:

Boron, carborane, borane, boron neutron capture therapy, radionuclides, anticancer drugs.



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Article Details

Volume: 6
Issue Number: 2
First Page: 75
Last Page: 109
Page Count: 35
DOI: 10.2174/187152006776119180
Price: $58
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