Understanding Apoptosis in Terms of QSAR

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Understanding Apoptosis in Terms of QSAR



Anti-Cancer Agents in Medicinal Chemistry, 6(1): 41-52.

Author(s): Rajeshwar P Verma.

Affiliation: Department of Chemistry, Pomona College, Claremont, CA 91711, USA;

Abstract

Apoptosis is a cellular mechanism by which unwanted, defective, or damaged cells are rapidly and selectively eliminated to maintain healthy tissue homeostasis in multi-cellular organisms. In this review, we have developed nineteen quantitative structure-activity relationships (QSAR) for different series of compounds with respect to their apoptotic activities against five different cancer cell lines that are T47D, ZR75-1, DLD-1, H1299, and HL60 in order to understand chemical-biological interactions.

Keywords:

Apoptosis, hydrophobicity, molar refractivity, molar volume, quantitative structure-activity relationship (QSAR).



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Article Details

Volume: 6
Issue Number: 1
First Page: 41
Last Page: 52
Page Count: 12
DOI: 10.2174/187152006774755528
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