A Novel Cobalt(II) Coordination Complex Constructed from H<sub>2</sub>Pyri and 4,4′-Bipy: Synthesis, Characterization and Bioactivity

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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A Novel Cobalt(II) Coordination Complex Constructed from H2Pyri and 4,4′-Bipy: Synthesis, Characterization and Bioactivity

Anti-Cancer Agents in Medicinal Chemistry, 15(6): 783-792.

Author(s): Enjun Gao, Fuchen Zhao, Mingchang Zhu and Meilin Wang.

Affiliation: Department of Coordination Chemistry, Shenyang University of Chemical Technology, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang 110142, China.


The new complex of {[Co(4,4′-Bipy)(H2O)4]·(Pyri)·3H2O}n (4,4′-Bipy = 4,4′-bipyridyl, H2Pyri = 3,5- Pyridinedicarboxylic acid) was synthesized and characterized by IR, element analysis and X-ray single-crystal diffraction. The binding of the complex with extracted HeLa cells DNA was investigated by UV and fluorescence spectrum. Gel electrophoresis assay demonstrated the ability of the complex cleaving the extracted HC-DNA. The complex exhibited a higher cytotoxicity against tumor cells in vitro. Furthermore, the apoptotic tests indicated the complex had an apoptotic effect on HeLa cells.


apoptosis, Cobalt(II) complex, cytotoxicity, gel electrophoresis.

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Article Details

Volume: 15
Issue Number: 6
First Page: 783
Last Page: 792
Page Count: 10
DOI: 10.2174/187152061506150610152136
Price: $58
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