Chemomodulating Effects of Flavonoids in Human Leukemia Cells

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Chemomodulating Effects of Flavonoids in Human Leukemia Cells

Anti-Cancer Agents in Medicinal Chemistry, 15(9): 1112-1126.

Author(s): Katrin Sak and Hele Everaus.

Affiliation: Department of Hematology and Oncology, University of Tartu, L. Puusepa 8, 51014 Tartu, Estonia.


Flavonoids, a diverse class of polyphenolic compounds, are well known for their anticancer properties. Moreover, it is generally accepted that these plant secondary metabolites can also sensitize malignant cells to conventional chemotherapeutic drugs and could thus be considered as potential adjunctive agents in cancer treatment. In this review article we show that besides potentiating the anticancer activity of standard chemotherapeutics by modifying the molecular events that are involved in cell growth, differentiation and apoptosis, flavonoids might also act as inhibitory modulators in human leukemia cells. The specific behavior of a certain flavonoid in such combination treatments is multifactorial being dependent on various aspects, including cellular context, molecular mechanisms of clinical drugs, temporal regimen of administration, as well as doses of agents. Based on the highly complex nature of leukemogenesis it is feasible that a multifaceted therapeutic approach is also required to cure this disease and therefore, combined chemotherapeutic schemes incorporating natural plant metabolites as chemosensitizing agents can represent a new attractive strategy for more successful treatment of leukemia patients in the future. However, as highlighted in this review, caution should be taken when affecting malignant cells concurrently with chemotherapeutic drugs and flavonoids as unwisely chosen combinations can lead to inadvisable results and sometimes even deteriorate the clinical outcomes.


Chemotherapy drugs, chemosensitization, flavonoids, inhibitory modulation, leukemia cells, signaling mechanisms.

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Article Details

Volume: 15
Issue Number: 9
First Page: 1112
Last Page: 1126
Page Count: 15
DOI: 10.2174/1871520615666150519112513
Price: $58

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