Anti-resorptive Drugs and their Impact on Maxillofacial Bone among Cancer Patients

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Anti-resorptive Drugs and their Impact on Maxillofacial Bone among Cancer Patients

Anti-Cancer Agents in Medicinal Chemistry, 15(6): 736-743.

Author(s): Farzad Borumandi, Tara Aghaloo, Luke Cascarini, Alexander Gaggl and Kunmi Fasanmade.

Affiliation: Oxford University Hospitals, Department of Oral, and Maxillofacial Surgery, Churchill Hospital and, John Radcliffe Hospital, Oxford, United Kingdom.


This article aims to give an overview on etiology, diagnosis and treatment options of osteonecrosis of the jaw bone among cancer patients receiving anti-resorptive drugs (ARDs). The physiologic bone function of continuous resorption and buildup is modified by the use of ARDs. Although ARDs proved to reduce pain and to improve the quality of life in patients with metastasizing bone disease, side effects such as medication related osteonecrosis of jaw bone (MRONJ) have been frequently reported since ARDs were firstly introduced. The new generation of ARDs such as Denosumab is associated with the same incidence of MRONJ among cancer patients. The etiology of MRONJ is not entirely understood and many hypotheses have been proposed. ARDs can modify the hard tissues directly by accumulation in the bone, or indirectly by suppression of the osteoclasts, inhibition of angiogenesis and vascularity. Some ARDs such as Bisphosphonates have reportedly the capacity to interfere directly and indirectly with the bone physiology. MRONJ can be a debilitating disease with non healing freely exposed bone in the oral cavity in patients, who already suffer from a primary cancerous disease. Knowledge of MRONJ as a potential side effect of ARDs is crucial for health professionals treating patients with bone modulating drugs.


Anti-resorptive drugs, bisphosphonates, denosumab, jaw necrosis, osteoporosis.

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Article Details

Volume: 15
Issue Number: 6
First Page: 736
Last Page: 743
Page Count: 8
DOI: 10.2174/1871520615666150325232857
Price: $58

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