The Applications of Targeting Anti-Cancer Agents in Cancer Therapeutics

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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The Applications of Targeting Anti-Cancer Agents in Cancer Therapeutics

Anti-Cancer Agents in Medicinal Chemistry, 15(7): 869-880.

Author(s): Guang-Chun Sun, X u Yang, Yan Yu and Dai-Wei Zhao.

Affiliation: Department of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University; 801 He-Qing Rd., Shanghai 200240, China.


Anti-cancer targeting drugs appear to be a new and powerful "weapon" for cancer therapies. These targeting drugs are directed against specific molecules that are over-expressed or where certain unique factors are aberrantly expressed either in cancer cells or in diseased cell sites. Compared with traditional chemotherapeutic drugs, these targeting drugs have the advantages of high specificity, efficacy and less side effects. Target therapy is a breakthrough and revolutionary advance in the field of cancer therapy. Tumor angiogenesis plays a key role in tumor growth and metastasis and the mutation of tyrosine kinases is also strongly associated with cancer progression. Thus, in this review, we will discuss the advances in the development of targeting anti-cancer drugs by narrowing it down to small molecule tyrosine kinase inhibitors, monoclonal antibodies against epidermal growth factor receptors belonging to the ErbB family of receptor tyrosine kinases and angiogenic inhibitors. It will also address concerns for drug resistance and adverse events.


Angiogenesis, cancer, combination therapy, signaling pathway, target therapy, tyrosine kinase.

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Article Details

Volume: 15
Issue Number: 7
First Page: 869
Last Page: 880
Page Count: 12
DOI: 10.2174/1871520615666150318101845
Price: $58

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