Apigenin and Breast Cancers: From Chemistry to Medicine

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Apigenin and Breast Cancers: From Chemistry to Medicine



Anti-Cancer Agents in Medicinal Chemistry, 15(6): 728-735.

Author(s): Seyed Mohammad Nabavi, Solomon Habtemariam, Maria Daglia and Seyed Fazel Nabavi.

Affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Abstract

Breast cancer is one of the most common causes of the death among women worldwide. Metabolic disorders, alcohol consumption, hormone replacement therapy, genetic susceptibility and not having children are well known risk factors for breast cancer. Surgical resection, radiation therapy, and chemotherapy are among the limited treatment options for breast cancer. Thus, there is growing need to find new chemopreventive agents that may be effective in prevention and/or management of breast cancer. Natural products such as flavonoids provide a variety of anticancer compounds which can be useful for prevention or treatment of breast cancer. The usefulness of dietary phytochemicals in the prevention of this disease is supported by a plethora of experimental and epidemiological studies. Apigenin, a well-known flavone, is found in several dietary plant foods such as parsley, celery, thyme, celeriac, chamomile, onions, lemon balm, and oranges. Extensive studies have shown that apigenin have potent antioxidant, anti-inflammatory, and anticarcinogenic properties. The aim of the present communication is to establish the therapeutic potential of apigenin against breast cancer through critical analysis of data from 5 in vitro and in vivo studies. We also review the molecular mechanisms underlying the anticancer effects, natural sources, bioavailability, as well as the chemistry of apigenin.




Keywords:

Apigenin, apoptosis, aromatase activity, breast cancer.



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Article Details

Volume: 15
Issue Number: 6
First Page: 728
Last Page: 735
Page Count: 8
DOI: 10.2174/1871520615666150304120643
Price: $58
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