Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance



Anti-Cancer Agents in Medicinal Chemistry, 15(4): 423-432.

Author(s): Shuaizhang Li, Wen Zhang, Xuejiao Yin, Shilai Xing, Heidi Qunhui Xie, Zhengyu Cao and Bin Zhao.

Affiliation: Research Center for Eco- Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Abstract

The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.




Keywords:

ATP-binding cassette (ABC) transporter, cancer, inhibitors, multi-drug resistance, substrate.



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Article Details

Volume: 15
Issue Number: 4
First Page: 423
Last Page: 432
Page Count: 10
DOI: 10.2174/1871520615666150129212723
Price: $58
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