Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Antitumor Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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Current: 2.722
5 - Year: 2.849

Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Antitumor Agents



Anti-Cancer Agents in Medicinal Chemistry, 15(8): 1049-1065.

Author(s): Mahamadhanif S. Shaikh, Rajshekhar Karpoormath, Neeta Thapliyal, Rajesh A. Rane, Mahesh B. Palkar, A.M. Faya, Harun M. Patel, Wesam S. Alwan, Kavita Jain and Girish A Hampannavar.

Affiliation: Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban – 4000, South Africa.

Abstract

Throughout our evolution, the importance of natural products for medicine and health has been increasing and it continues to be a key source of novel anticancer drugs, leads and new chemical entities. Among natural products, tricyclic heteroaromatic alkaloids such as carbazoles are an important class of natural and semi-synthetic organic compounds. In the last few decades medicinal role of natural and semi-synthetic carbazoles has expanded significantly, especially as a vital heterocyclic class of antitumor agents. Some of the carbazoles that displayed potential anticancer activity have undergone clinical trials. However, complications arising due to multidrug resistance in clinical trials led to very few of the selected carbazoles being approved for cancer therapy. Planar, polycyclic and aromatic carbazoles exhibit anticancer activity via DNA intercalation. Further many carbazoles can be cytotoxic by inhibiting DNA-dependent enzymes such as telomerase and topoisomerase I/II.




Keywords:

Anticancer agent, antitumor agent, carbazole alkaloids, review.



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Article Details

Volume: 15
Issue Number: 8
First Page: 1049
Last Page: 1065
Page Count: 17
DOI: 10.2174/1871520615666150113105405
Price: $58
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