Acridone-based Antitumor Agents: A Mini-review

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Acridone-based Antitumor Agents: A Mini-review



Anti-Cancer Agents in Medicinal Chemistry, 15(8): 1012-1025.

Author(s): Wesam S. Alwan, Anand A. Mahajan, Rajesh A. Rane, Anish A. Amritkar, Shital S. Naphade, Mayur C. Yerigiri and Rajshekhar Karpoormath.

Affiliation: Sinhgad Institute of Pharmacy, Narhe, Pune - 411041, affiliated to University of Pune, India.

Abstract

In the past decades, tricyclic acridone ring system has become one of the major research interests of the medicinal chemists due to the biological significance of this moiety in drug design and drug discovery. Acridone scaffold has substantial bio-potential since it possess crucial activities such as antibacterial, antimalarial, antiviral and anti-neoplastic. The diverse biological activity of acridone and its prospective in reversal of multi-drug resistance has attracted attention of medicinal chemists to explore this scaffold especially to treat multi-drug resistance in cancer. Considering this potential in this review we have summarized the synthesis and the antitumor activities of different acridone derived compounds reported from 2000 to 2014.




Keywords:

Acridone, antitumor, natural product, synthesis.



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Article Details

Volume: 15
Issue Number: 8
First Page: 1012
Last Page: 1025
Page Count: 14
DOI: 10.2174/1871520615666150113104457
Price: $58
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