Recent Advance in Drug Development of Squamous Cell Carcinoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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5 - Year: 2.849

Recent Advance in Drug Development of Squamous Cell Carcinoma

Anti-Cancer Agents in Medicinal Chemistry, 15(7): 816-827.

Author(s): Jun Lei, Bing Fu, Hang Yin, Guanxiu Tang, Shujuan Zhu, Chunli Yan and Quanyong He.

Affiliation: Central South University.


Squamous cell carcinoma (SCC) has a high worldwide incidence that is commonly seen as head and neck cancers, esophageal cancers, and non-small cell lung cancers. There is a poor prognosis for SCC due to potential recurrence and its metastatic tendency so the 5-year survival rate is very low. Target therapy is a novel and promising treatment strategy exhibiting great anti-tumor effects and survival benefits in SCC. This review summarizes current treatment strategies from clinical and experimental studies, including the agents targeting epidermal growth factor receptors, RNA polymerase, toll-like receptors, p38α MAPK, CXCR, and the related combination therapy regimens. However, there are still many challenges we have to face. It is a burning need to improve the development and availability of drug formulations.


Drug, epidermal growth factor receptor, esophageal, head and neck, lung, squamous cell carcinoma, target therapy, toll-like receptor.

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Article Details

Volume: 15
Issue Number: 7
First Page: 816
Last Page: 827
Page Count: 12
DOI: 10.2174/1871520615666150113103938
Price: $58

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