Encouraging microRNA-based Therapeutic Strategies for Hepatocellular Carcinoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Encouraging microRNA-based Therapeutic Strategies for Hepatocellular Carcinoma



Anti-Cancer Agents in Medicinal Chemistry, 15(4): 453-460.

Author(s): Min Yao, Li Wang, Liwei Qiu, Qi Qian and Dengfu Yao.

Affiliation: vResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with poor prognosis. Most of the HCC patients died quickly because of the rapid tumor progression with no effective therapy except for liver resection or transplantation. Recently, microRNAs (miRNAs) have emerged as key factors involved in a series of biological processes ranging from embryogenesis to programmed cell death with aberrant expression profiles, potentially attractive diagnosis, prognosis or therapeutic applications for related-diseases. Accumulating evidences have indicated the roles of miRNAs as tumor suppressor in hepatocyte malignant transformation including development, differentiation, proliferation and tumorigenesis. This article reviews that the recent progress underlies the development of novel miRNA-based HCC therapeutic strategies in the coming future.




Keywords:

Hepatocellular carcinoma, microRNA, molecular target, therapy.



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Article Details

Volume: 15
Issue Number: 4
First Page: 453
Last Page: 460
Page Count: 8
DOI: 10.2174/1871520615666141216150135
Price: $58
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