Tea (Camellia sinensis (L.)): A Putative Anticancer Agent in Bladder Carcinoma?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Tea (Camellia sinensis (L.)): A Putative Anticancer Agent in Bladder Carcinoma?



Anti-Cancer Agents in Medicinal Chemistry, 15(1): 26-36.

Author(s): Vanessa R. Conde, Marco G. Alves, Pedro F. Oliveira and Branca M Silva.

Affiliation: Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6201-506 Covilha, Portugal.

Abstract

The leaves of Camellia sinensis (L.) are the source of tea, the second most consumed beverage worldwide. Tea contains several chemical compounds such as polyphenols (mainly catechins), caffeine, theophylline, L-theanine, among many others. Polyphenolic compounds are mainly responsible for its significant antioxidant properties and anticarcinogenic potential. Bladder cancer is one of the most common types of cancer, and its progression and onset are thought to be controlled by dietary and lifestyle factors. Epidemiological studies showed that the regular consumption of tea can be a preventive factor for this type of cancer, and several in vivo and in vitro studies reported that tea and its components may interfere in the cancer cells’ signaling, preventing the bladder tumor progression. The mechanisms responsible for this protection include deregulation of cell cycle, induction of apoptosis while protecting the surrounding healthy bladder cells, inhibition of metastization processes, among others. Herein, we discuss the potential beneficial effects of tea and tea components in bladder cancer prevention and/or treatment, and how they can be helpful in finding new therapeutic strategies to treat this type of cancer.




Keywords:

Bladder cancer, caffeine, Camellia sinensis, catechins, EGCG, polyphenols.



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Article Details

Volume: 15
Issue Number: 1
First Page: 26
Last Page: 36
Page Count: 11
DOI: 10.2174/1566524014666141203143143
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