Bergamot Juice Extract Inhibits Proliferation by Inducing Apoptosis in Human Colon Cancer Cells

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Bergamot Juice Extract Inhibits Proliferation by Inducing Apoptosis in Human Colon Cancer Cells

Anti-Cancer Agents in Medicinal Chemistry, 14(10): 1402-1413.

Author(s): Giuseppa Visalli, Nadia Ferlazzo, Santa Cirmi, Pietro Campiglia, Sebastiano Gangemi, Angela Di Pietro, Gioacchino Calapai and Michele Navarra.

Affiliation: Department of Drug Sciences and Products for Health, University of Messina, viale Annunziata, 98168, Messina, Italy.


Colorectal cancer (CRC) is a leading cause of cancer mortality in the industrialized world, second to lung cancer. A lot of evidences highlight that a diet rich in fruits and vegetables may reduce the risk of some types of cancer including CRC. In this study we demonstrate that Citrus bergamia juice extracts (BJe) reduces CRC cell growth by multiple mechanisms. Low BJe concentrations inhibit MAPKs pathway and alter apoptosis-related proteins, that in turn induce cell cycle arrest and apoptosis in HT-29 cells. Instead, high concentrations of BJe induce oxidative stress causing DNA damage. Our study highlights the role of BJe as modulator of cell apoptosis in CRC cells and strengthens our previous hypothesis that the flavonoid fraction of bergamot juice may play a role as anti-cancer drug.


Apoptosis, antiproliferative activity, Citrus bergamia, colorectal cancer, flavonoids, complementary and alternative medicine, HT-29 cells, natural products.

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Article Details

Volume: 14
Issue Number: 10
First Page: 1402
Last Page: 1413
Page Count: 12
DOI: 10.2174/1871520614666140829120530
Price: $58

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