New Perspective on the Dual Functions of Indirubins in Cancer Therapy and Neuroprotection

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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New Perspective on the Dual Functions of Indirubins in Cancer Therapy and Neuroprotection



Anti-Cancer Agents in Medicinal Chemistry, 14(9): 1213-1219.

Author(s): Ying Wang, Pui Man Hoi, Judy Yuet-Wa Chan and Simon M-Y Lee.

Affiliation: State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China.

Abstract

Indirubin is an active ingredient mainly used to treat leukemia in China and is reported to be a leading inhibitor of cyclindependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) by competing with ATP binding sites. New findings have indicated that its comprehensive structure may contribute to its polypharmacological activities particularly in cancer and neurodegenerative disease therapy, as both of these diseases are usually accompanied by a common molecular link related to abnormal phosphorylation of CDKs and GSK-3. In the elderly, cancer and neurodegenerative disease are tightly associated common diseases and sometimes unavoidably coexist. In this review, the underlying mechanisms of the dual actions of indirubin and its structurally-related compounds in cancer and neurodegenerative disease therapy are presented.




Keywords:

cancer, CDKs, dual function, GSK-3, indirubin, neurodegeneration.



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Article Details

Volume: 14
Issue Number: 9
First Page: 1213
Last Page: 1219
Page Count: 7
DOI: 10.2174/1871520614666140825112924
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