Anticancer Activity and Mechanism Investigation of Beauvericin Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Anticancer Activity and Mechanism Investigation of Beauvericin Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi



Anti-Cancer Agents in Medicinal Chemistry, 15(2): 258-266.

Author(s): Yi-wen Tao, Yong-cheng Lin, Zhi-gang She, Min-ting Lin, Pin-xian Chen and Jian-ye Zhang.

Affiliation: School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 510182, the People's Republic of China.

Abstract

One known cyclic peptide, beauvericin, was isolated from the secondary metabolites of mangrove endophytic fungi Fusarium sp. (No. DZ27) in South China Sea. Its structure was determined by spectral analyses and comparisons with reference data from literatures. Beauvericin inhibited growth of KB and KBv200 cells potently with IC50 values of 5.76 ± 0.55 and 5.34 ± 0.09 μM, respectively. Furthermore, beauvericin induced apoptosis through mitochondrial pathway, including decrease of relative oxygen species generation, loss of mitochondrial membrane potential, release of cytochrome c, activation of Caspase-9 and -3, and cleavage of PARP. Additionally, regulation of Bcl-2 or Bax was not involved in the apoptosis induced by beauvericin in KB and KBv200 cells.




Keywords:

Anti-cancer activity, apoptosis, beauvericin, mangrove endophytic fungi, mitochondrial pathway, peptide.



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Article Details

Volume: 15
Issue Number: 2
First Page: 258
Last Page: 266
Page Count: 9
DOI: 10.2174/1871520614666140825112255
Price: $58
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