Translational Gap in Glioma Research

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Translational Gap in Glioma Research

Anti-Cancer Agents in Medicinal Chemistry, 14(8): 1110-1120.

Author(s): Chi Ma, Gang Zhao, Mabel Hilda Cruz, Ake Siden and Juan Sebastian Yakisich.

Affiliation: Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden, S-141 86.


During the last five decades, enormous advances in treatment modalities for cancer and a better understanding of cancer cell biology have been accomplished but the prognosis of patients carrying malignant gliomas still remains poor despite hundreds of clinical trials have been carried out. In this article we review phase II clinical trials that have been completed and published in PubMed during 2011 in order to investigate potential reasons of clinical failure. We suggest that a translational gap, defined as a failure to translate basic research into clinical trials design may explain the poor outcome of phase II clinical trials.


Clinical trial, Glioma, phenotype, stem cells, stem cell theory, stemness.

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Article Details

Volume: 14
Issue Number: 8
First Page: 1110
Last Page: 1120
Page Count: 11
DOI: 10.2174/1871520614666140825110907
Price: $58

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