From French Paradox to Cancer Treatment: Anti-cancer Activities and Mechanisms of Resveratrol

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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From French Paradox to Cancer Treatment: Anti-cancer Activities and Mechanisms of Resveratrol



Anti-Cancer Agents in Medicinal Chemistry, 14(6): 806-825.

Author(s): Xuan Yang, Xun Li and Jinyu Ren.

Affiliation: The Second Department of General Surgery, the First Hospital of Lanzhou University, Donggang West Rd No.1, Lanzhou, 730000, Gansu, China.

Abstract

Resveratrol (3, 5, 4’-trihydroxy-trans-stilbene, RVT), a stilbenoid, polyphenol phytochemical present in berries, grape, peanuts and wine. It has been suggested as a major contributor to “French Paradox” that reduces the mortality from coronary heart disease (CHD) by consuming RVT in red wine even in some of French population with a high-fat intake. With extensive research, it has been found that RVT is a versatile and pleiotropic agent, it not only possesses cardiovascular-protective benefits by its powerful antioxidant capacity, anti-inflammatory, regulating metabolism and anti-aging effects, but also has strong anti-tumor activities through inhibiting tumor cell proliferation, inducing cell apoptosis, promoting tumor cell differentiation, preventing tumor invasion and metastasis, and further moderating the host immune system to kill tumor cells. This review will focus on RVT’s anti-tumor activity and tumor prevention potential including: the anti-tumor spectrum in vitro and in vivo; molecular targets and signal pathways involving RVT anti-tumor mechanisms; evidences from clinical trial for its bioavailability, dosage, toxicity and benefit in humans; and its prospective including its analog, deviations, and combinative chemotherapy.

Keywords:

Anti-cancer activity, cancer therapy, mechanisms, paradox, resveratrol.



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Article Details

Volume: 14
Issue Number: 6
First Page: 806
Last Page: 825
Page Count: 20
DOI: 10.2174/1871520614666140521121722
Price: $58
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