Garlic-Derived Allyl Sulfides in Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Garlic-Derived Allyl Sulfides in Cancer Therapy



Anti-Cancer Agents in Medicinal Chemistry, 14(6): 793-799.

Author(s): Hai-Xia Cao, Ke-Xiang Zhu, Jian-Gao Fan and Liang Qiao.

Affiliation: Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of medicine, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China.

Abstract

Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underlying mechanisms are not completely understood. In this mini-review, we aim to summarize the reported biological effects of garlic products as anti-tumor agents, and present the possible molecular mechanisms responsible for the anti-carcinogenesis effects of garlic and its derivatives.

Keywords:

Allyl sulfides, apoptosis, carcinogenesis, cell cycle, Garlic, organosulfur compounds.



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Article Details

Volume: 14
Issue Number: 6
First Page: 793
Last Page: 799
Page Count: 7
DOI: 10.2174/1871520614666140521120811
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