Current View on the Mechanism of Action of Perifosine in Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Current: 2.722
5 - Year: 2.849

Current View on the Mechanism of Action of Perifosine in Cancer



Anti-Cancer Agents in Medicinal Chemistry, 14(4): 629-635.

Author(s): Joachim Fensterle, Babette Aicher, Irene Seipelt, Michael Teifel and Juergen Engel.

Affiliation: Aeterna Zentaris, Weismuellerstr. 50, 60314 Frankfurt, Germany.

Abstract

Perifosine treatment exhibits a complex molecular response including the inhibition of Akt or the induction of apoptosis via clustering of death receptors in lipid rafts. However, the molecular response can vary between different tumor entities and the contribution of each target pathway to the activity of Perifosine might be distinct depending on the tumor entity or the agent combined with Perifosine.

In this review we discuss the current view on the mechanism of action of perifosine in cancer and the contribution of the molecular targets of Perifosine to its activity.


Keywords:

APL miltefosine, cancer, perifosine.



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Article Details

Volume: 14
Issue Number: 4
First Page: 629
Last Page: 635
Page Count: 7
DOI: 10.2174/1871520614666140309225912
Price: $58
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