Colorectal Cancer in Elderly Patients: From Best Supportive Care to Cure

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Colorectal Cancer in Elderly Patients: From Best Supportive Care to Cure

Anti-Cancer Agents in Medicinal Chemistry, 13(9): 1332-1343.

Author(s): Massimiliano Berretta, Fabrizio Di Benedetto, Raffaele Di Francia, Emanuele Lo Menzo, Sergio Palmeri, Umberto Tirelli and Paolo De Paoli.

Affiliation: Department of Medical Oncology, National Cancer Institute, Via Franco Gallini 2 - 33081 Aviano (PN) – Italy


Colorectal cancer is one of the major causes of cancer mortality in the elderly population (median age at diagnosis of 71 years) in Western Countries. Moreover patients with metastatic disease are often elderly with significant co- morbidities. Unfortunately, elderly patients are often untreated and under-represented in clinical trials, even if most clinical trials that have included this setting of population have shown similar survival rates and toxicities to younger patients.

Age itself should not be considered for candidacy to chemotherapy but it should be taken in consideration the great heterogeneity of co-morbidities present in the elderly population. Therefore, the best treatment strategy for elderly colorectal cancer patients has not yet been defined. Comprehensive Geriatric Assessment is recommended to evaluate the best strategy treatment and to reduce the adverse events. In fact, while fit elderly patients could receive the same therapeutic treatment as the younger counterpart, a palliative approach should be taken in consideration for frail elderly patients and for those with a short life expectancy.


Elderly, colorectal, cancer, chemotherapy, treatment.

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Article Details

Volume: 13
Issue Number: 9
First Page: 1332
Last Page: 1343
Page Count: 12
DOI: 10.2174/18715206113136660350
Price: $58
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