Onco-Surgical Management of Colo-Rectal Liver Metastases in Older Patients: A New Frontier in the 3<sup>rd</sup> Millennium

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Onco-Surgical Management of Colo-Rectal Liver Metastases in Older Patients: A New Frontier in the 3rd Millennium

Anti-Cancer Agents in Medicinal Chemistry, 13(9): 1354-1363.

Author(s): Fabrizio Di Benedetto, Giuseppe D’Amico, Mario Spaggiari, Umberto Tirelli and Massimiliano Berretta.

Affiliation: Hepato-Biliary-Pancreatic Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, Italy.


Colorectal cancer (CRC) is one the most common malignant tumors in industrialized countries today. Over half of all cancers are currently diagnosed in elderly patients, and 76% of all colorectal cancer patients are diagnosed between 65 and 85 years old. Elderly patients are less likely to undergo curative surgery, and less likely to be offered the option of metastasectomy when colorectal liver metastases (CLM) are present. Hepatic resection has become the standard care for the treatment of isolated CLM. However, in studies reporting resection of CLM only 8-20% of the patients are older than 70 years. When balancing the benefits of surgical resection of liver metastases against the potential risks of surgery, many clinicians are still reluctant to advise in favor of surgical treatment in the elderly. Factors other than age should also be considered when evaluating surgical risk in the elderly, for example, conditions such as heart disease and diabetes have been shown to induce life-threatening postoperative complications. Age alone need not be a contraindication to aggressive surgical therapy in this group, rather, appropriate selection criteria based on tumor characteristics and general medical fitness, similar to those used for younger patients, should be applied.


Colorectal liver metastases, Elderly patients, Onco-surgical management, Morbility and mortality.

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Article Details

Volume: 13
Issue Number: 9
First Page: 1354
Last Page: 1363
Page Count: 10
DOI: 10.2174/18715206113136660344
Price: $58
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