Hepatocellular Carcinoma: Beyond the Boundaries of Age

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Hepatocellular Carcinoma: Beyond the Boundaries of Age

Anti-Cancer Agents in Medicinal Chemistry, 13(9): 1371-1377.

Author(s): Fabrizio Di Benedetto, Giuseppe Tarantino, Cristiano Quintini, Umberto Tirelli and Massimiliano Berretta.

Affiliation: Hepato-Biliary-Pancreatic Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia. Via del Pozzo, 71; 41100, Modena, Italy.


Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide, and the management of HCC has radically changed in recent years. Over the last few years, many elderly patients have been considered less amenable to effective treatments compared to younger patients, due to the accumulation of different diseases during their lives. This assumption has now been reviewed and some key points have been outlined such as the necessity of a careful selection of patients, which may lead to satisfactory results after the treatment of elderly patients with HCC. The purpose of this study was to make a comprehensive analysis of results from the literature concerning the multimodal treatment of HCC in elderly patients, analyzing the therapeutic options such as liver resection, ablative treatments, liver transplantation and targeted chemotherapy.


Hepatocellular carcinoma, elderly, liver resection, ablative treatment, sorafenib, liver transplantation, review.

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Article Details

Volume: 13
Issue Number: 9
First Page: 1371
Last Page: 1377
Page Count: 7
DOI: 10.2174/18715206113136660342
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