The Interaction Between FAK, MYCN, p53 and Mdm2 in Neuroblastoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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The Interaction Between FAK, MYCN, p53 and Mdm2 in Neuroblastoma



Anti-Cancer Agents in Medicinal Chemistry, 14(1): 46-51.

Author(s): Alicia M. Waters and Elizabeth A Beierle.

Affiliation: University of Alabama at Birmingham, 1600 7th Ave. South, Lowder Room 300, Birmingham, AL 35233, USA.

Abstract

Neuroblastoma tumorigenesis and malignant transformation is driven by overexpression and dominance of cell survival pathways and a lack of normal cellular senescence or apoptosis. Therefore, manipulation of cell survival pathways may decrease the malignant potential of these tumors and provide avenues for the development of novel therapeutics. This review focuses on the individual protein tyrosine kinase, focal adhesion kinase (FAK) and its interaction with the transcription factors, MYCN, p53, and Mdm2, and how their interactions modulate the growth and malignancy of neuroblastomas.

Keywords:

FAK, Mdm2, MYCN, neuroblastoma, p53.



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Article Details

Volume: 14
Issue Number: 1
First Page: 46
Last Page: 51
Page Count: 6
DOI: 10.2174/18715206113136660331
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