Evidence for Anti-Cancer Properties of Blueberries: A Mini-Review

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Evidence for Anti-Cancer Properties of Blueberries: A Mini-Review

Anti-Cancer Agents in Medicinal Chemistry, 13(8): 1142-1148.

Author(s): Sarah A. Johnson and Bahram H Arjmandi.

Affiliation: Department of Nutrition, Food and Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA.


Blueberries are amongst the most commonly consumed berries in the United States. Berries in general are rich in phenolic compounds, which are known for their high antioxidant capacity. Specifically, evidence from in vitro, in vivo and a few clinical studies suggest that blueberries and their active constituents show promise as effective anti-cancer agents, both in the form of functional foods and as nutritional supplements. Some of the mechanisms by which blueberries have been shown to prevent carcinogenesis include inhibition of the production of pro-inflammatory molecules, oxidative stress and products of oxidative stress such as DNA damage, inhibition of cancer cell proliferation and increased apoptosis. This review will focus on the preclinical and clinical evidence that supports blueberries as an anti-cancer fruit, as well as expressing the need for more preclinical studies and the conduction of clinical studies with respect to the cancer preventive ability of blueberries.


Antioxidant, cancer prevention, carcinogenesis, chemoprevention, DNA damage, functional food, inflammation, oxidative stress, polyphenol, pterostilbene, tumorigenesis, vaccinium.

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Article Details

Volume: 13
Issue Number: 8
First Page: 1142
Last Page: 1148
Page Count: 7
DOI: 10.2174/18715206113139990137
Price: $58

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