Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides



Anti-Cancer Agents in Medicinal Chemistry, 14(2): 331-340.

Author(s): Katerina Tmejova, Ludmila Krejcova, David Hynek, Vojtech Adam, Petr Babula, Libuse Trnkova, Marie Stiborova, Tomas Eckschlager and Rene Kizek.

Affiliation: Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic, European Union.

Abstract

Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too.

Keywords:

Adsorptive transfer stripping technique, DNA, differential pulse voltammetry, ellipticine, hetero-nucleotides, intercalation, square wave voltammetry, cancer, therapy.



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Article Details

Volume: 14
Issue Number: 2
First Page: 331
Last Page: 340
Page Count: 10
DOI: 10.2174/18715206113139990316
Price: $58
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