Effects of Limonoid Cedrelone on MDA-MB-231 Breast Tumor Cells in vitro

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Effects of Limonoid Cedrelone on MDA-MB-231 Breast Tumor Cells in vitro

Anti-Cancer Agents in Medicinal Chemistry, 13(10): 1645-1653.

Author(s): Angelina M. Fuzer, Júlio César C. Filho, Amanda B. Becceneri, Damiana A. dos Santos, Maria Fátima das G. F. da Silva, Paulo C. Vieira, João B. Fernandes, Heloisa S. Selistre-de-Araujo, Cristiane M. Cazal and Márcia R Cominetti.

Affiliation: Departamento de Gerontologia, Universidade Federal de São Carlos, Rodovia Washington Luís, Km 235, CEP 13565-905, São Carlos, SP, Brazil.


Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compounds which could be the basis for the design of new anti-tumor drugs, with fewer side effects than the conventional chemotherapy used currently. Cedrelone is a limonoid isolated from Trichilia catigua (Meliaceae) which is a native Brazilian plant. This study demonstrates that cedrelone inhibits proliferation, adhesion, migration and invasion of breast tumor cells from the line MDA-MB-231. The effects of cell migration and invasion on MDA-MB-231 cell may be explained, at least in part, by the ability of cedrelone to inhibit MMP activity. We also demonstrate that cedrelone is able to induce apoptosis in MDA-MB-231 cells. There are only a few works investigating the effect of limonoids in cellular processes closely related to tumor progression such as adhesion, migration and invasion. To the best of our knowledge, this is the first work describing the effects of a limonoid on tumor and non-tumor cell adhesion process.


Apoptosis, cancer, cedrelone, cell adhesion, limonoid, natural products.

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Article Details

Volume: 13
Issue Number: 10
First Page: 1645
Last Page: 1653
Page Count: 9
DOI: 10.2174/18715206113139990314
Price: $58
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