Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents



Anti-Cancer Agents in Medicinal Chemistry, 13(7): 1048-1056.

Author(s): Hui Sun, Zhaoye Wang and Juan Sebastian Yakisich.

Affiliation: Department of Clinical Neuroscience R54, Karolinska University Hospital, Stockholm, Sweden, S-141 86.

Abstract

The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a key regulator of authophagy. Natural products show anticancer activity and often induce apoptosis or autophagy. The crosstalk between these two types of cell death makes autophagy an interesting target since drugs targeting this process not only can induce cell death by inducing autophagy but can also sensitize cells to apoptosis. Autophagy is also a protective mechanism associated with increased resistance to chemotherapy. In this review, we discuss natural products known to induce autophagy cell death in cancer cells via the PI3K/Akt/mTOR pathway.

Keywords:

Natural products, PI3K/Akt, autophagy, cancer stem cell, stemness, cell death, anticancer drugs.



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Article Details

Volume: 13
Issue Number: 7
First Page: 1048
Last Page: 1056
Page Count: 9
DOI: 10.2174/18715206113139990130
Price: $58
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