Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer



Anti-Cancer Agents in Medicinal Chemistry, 13(7): 979-987.

Author(s): Wenxing Chen, Yin Lu, Guangying Chen and Shile Huang.

Affiliation: College of Pharmacy and Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China.

Abstract

Cryptotanshinone is one of the major tanshinones isolated from the roots of the plant Salvia miltiorrhiza Bunge (Danshen). Danshen has been widely used in traditional Chinese medicine for treatment of a variety of diseases, including coronary artery disease, acute ischemic stroke, hyperlipidemia, chronic renal failure, chronic hepatitis, and Alzheimer's disease, showing no serious adverse effects. Recent studies have shown that cryptotanshinone not only possesses the potential for treatment and prevention of the above-mentioned diseases, but also is a potent anticancer agent. Here we briefly summarize the physical and chemical properties and the pharmacokinetic profiles of cryptotanshinone, and then comprehensively review its anticancer activities as well as the underlying mechanisms.

Keywords:

Cryptotanshinone, tanshinones, cancer, cell proliferation, cell death, mTOR.



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Article Details

Volume: 13
Issue Number: 7
First Page: 979
Last Page: 987
Page Count: 9
DOI: 10.2174/18715206113139990115
Price: $58
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