Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention



Anti-Cancer Agents in Medicinal Chemistry, 13(7): 971-978.

Author(s): Xin Tong and Jill C Pelling.

Affiliation: Department of Pathology, Northwestern University, 303 E Chicago Ave, Ward building 3-140, Chicago, IL 60611, USA.

Abstract

Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin’s inhibition of the PI3K/Akt/mTOR signaling pathways.

Keywords:

Akt, mTOR, apigenin, cancer.



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Article Details

Volume: 13
Issue Number: 7
First Page: 971
Last Page: 978
Page Count: 8
DOI: 10.2174/18715206113139990119
Price: $58
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