Affiliation: Department of Medicine, University of Salerno and Division of Oncology, “San Giovanni di Dio e Ruggi d’Aragona” Hospital, Salerno.
The incidence of melanoma is rapidly increasing worldwide and the prognosis of patients with metastatic disease is still poor, with a median survival of 8–9 months and a 3-year overall survival (OS) rate less than 15% [1,2].
A complete surgical excision is the main treatment for primary cutaneous melanoma , but controversies about the extension of excision margins still remain .
Sentinel lymph node biopsy (SLNB) provides important prognostic and staging data by the identification of regional node-negative patients who would not benefit from a complete nodal dissection. However, there is no consensus in the definition of melanoma thickness to enforce the execution of the SLNB .
To date, Interferon-α (IFN-α)is the only approved adjuvant treatment after surgical excision of high-risk melanoma, but its indication remains still controversial [2,6].