Multidisciplinary Approach to Rectal Cancer: Are we Ready for Selective Treatment Strategies?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Multidisciplinary Approach to Rectal Cancer: Are we Ready for Selective Treatment Strategies?

Anti-Cancer Agents in Medicinal Chemistry, 13(6): 852-860.

Author(s): Antonio Avallone, Luigi Aloj, Paolo Delrio, Biagio Pecori, Alessandra Leone, Fabiana Tatangelo, Francesco Perri, Antonella Petrillo, Nigel Scott and Alfredo Budillon.

Affiliation: Gastrointestinal Medical Oncology, National Cancer Institute G.Pascale, Via M. Semmola, 80131 Napoli, Italy.


With optimized local treatment, achieved in the last years by TME surgery and the shift from a postoperative to a preoperative treatment approach, distant metastases have become the predominant mode of failure in rectal cancer. Therefore, the intensification of chemotherapy seems essential to improve distant control and survival in rectal cancer. The integration of newer generation chemotherapeutics and target agents into fluoropyrimidines-based chemoradiotherapy (CRT) has been the more actively pursued intensification strategy. However, early results from randomized phase III trials, evaluating the addition of oxaliplatin to preoperative fluoropyrimidines-based CRT, did not show a significant impact on early pathological response with the addition of oxaliplatin, with the exception of the German CAO/ARO/AIO-04 study. Moreover, the integration of target agents into preoperative CRT, although attractive in principle, has yielded low rates of pathologic complete responses when combined with cetuximab and some concerns on surgical morbidity following preoperative treatment with bevacizumab have been raised. Several novel strategies with different sequence of multimodal treatment components have been developed. However, the evidence that rectal cancers are a widely heterogeneous group of tumors with different prognostic implications, has indicated that the careful assessment of the risk of recurrence is a critical issue. In the era of the preoperative approach, staging with MRI, for its ability to predict the involvement of the mesorectal fascia, should be mandatory for all patients with rectal cancer, to refine the selection of patients for different treatment strategies. Moreover, considering that response to preoperative treatment is not uniformly obtained in all patients and post-operative chemotherapy is generally met with poor adherence, a risk-adapted strategy should be pursued in the postoperative setting as well. The selection of patients for different multidisciplinary treatment strategies based on clinico-pathological features, rather than the current “one size fits all” approach, will allow minimizing therapy and maximizing outcome for rectal cancer patients.


Rectal cancer, magnetic resonance imaging, chemo-radiotherapy, target therapy, organ preservation.

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Article Details

Volume: 13
Issue Number: 6
First Page: 852
Last Page: 860
Page Count: 9
DOI: 10.2174/18715206113139990123
Price: $58

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