Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status



Anti-Cancer Agents in Medicinal Chemistry, 13(4): 603-631.

Author(s): Karina Petit and Jean-Francois Biard.

Affiliation: University of Nantes, Faculty of Pharmacy, MMS – EA2160, 9 rue Bias, F-44000 Nantes, France.

Abstract

Marine ecosystems constitute a huge reservoir of biologically active secondary metabolites. Consequently during the last past few decades, several marine-derived molecules have been approved for anticancer treatment or are under clinical trials. This review reports the present state of the art of the sixteen molecules approved or currently on the clinical pipeline for anticancer chemotherapy. The molecules are classified according to their current status in the phase (approved / phase IV / phase III / phase II / phase I) and data are updated to April 2012.

Keywords:

Brentuximab vedotin, Clinical trials, Cytarabine, Elisidepsin, Eribulin, ILX-651, KLH, Marine natural products, MMAE, MMAF, Plinabulin, plitidepsin, PM00104, PM01183, PM060184, Salinosporamide A, Trabectedin, TZT-1027.



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Article Details

Volume: 13
Issue Number: 4
First Page: 603
Last Page: 631
Page Count: 29
DOI: 10.2174/1871520611313040010
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