Experimental and Theoretical Advances in Functional Understanding of Flavonoids as Anti-Tumor Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Experimental and Theoretical Advances in Functional Understanding of Flavonoids as Anti-Tumor Agents



Anti-Cancer Agents in Medicinal Chemistry, 13(2): 307-332.

Author(s): Bandarugattu V. Babu, Naveen K. Konduru, Waro Nakanishi, Satoko Hayashi, Naseem Ahmed and Petar M Mitrasinovic.

Affiliation: Department of Material Science and Chemistry, Faculty of Systems Engineering, Wakayama University, 930 Sakaedani, Wakayama, 640-8510 Japan.

Abstract

The potential of flavonoids to act as anti-tumor agents has been recognized but not fully understood because flavonoids are acting at several stages in cancer progression with distinct structure-function relationships. A whole family of structurally different flavonoids is herein described by reviewing some critical aspects of their pro-oxidant behavior in vitro/vivo and in cell systems by which they may work as antioxidants. Different classes of flavonoids (chalcones, flavones, isoflavones, flavanols, flavanones and anthocyanins) are synthetically mimicked using natural product structure-antioxidant activity relationships that are relevant for their enhanced function against cancer as well as severe inflammation conditions under which an increased oxidative stress is often implicated. In the context of the common mechanisms of flavonoid action, clinical data on benefits of flavonoids in fighting against cancer are discussed. A structural basis needed to improve antioxidant activity of these agents is elaborated in more detail.

Keywords:

Action, Anthocyanin, Anti-cancer agent, Antioxidant, Anti-tumor activity, Cell line, Chalcone, Clinical data, Cytotoxic activity, Flavone, Flavonoid, Flavanol, Flavanone, Flavopiridol, Function, Isoflavone, Mechanism, Quercetin, SAR, Structure .



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Article Details

Volume: 13
Issue Number: 2
First Page: 307
Last Page: 332
Page Count: 26
DOI: 10.2174/1871520611313020017
Price: $58
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