Progress in Evaluation of Pathologic Response to Neoadjuvant Chemotherapy of Breast Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Progress in Evaluation of Pathologic Response to Neoadjuvant Chemotherapy of Breast Cancer

Anti-Cancer Agents in Medicinal Chemistry, 13(2): 222-226.

Author(s): Estifanos P. Gebreamlak, Gary M.K. Tse and Yun Niu.

Affiliation: Breast Pathology of Department and Laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. Huan Hu Xi Road, Ti Yuan Bei, He Xi District, Tianjin, 300060, China.


Neoadjuvant chemotherapy is provided to patients with locally advanced breast cancer. Its main objective is to bring about a complete pathologic response which is correlated with long term patient survival, a clinical end point of preoperative chemotherapy. Besides, it may downsize the tumor, enabling breast conserving or limited mastectomy. Preoperative chemotherapy also provides the opportunity of assessing the chemosensitivity of the tumor in vivo so that postoperative chemotherapy is tailored according to the outcome of the neoadjuvant chemotherapy. Pathological complete response is considered when there is complete eradication of the local regional disease. Residual disease in the primary focus and/or axilla after preoperative chemotherapy is associated with poor prognosis. Standard preoperative and postoperative specimen collection, handling, processing, and examination are essential components of proper evaluation and reporting of pathologic response to neoadjuvant chemotherapy.


Breast cancer, Neoadjuvant chemotherapy, Histopathology, Pathology response.

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Article Details

Volume: 13
Issue Number: 2
First Page: 222
Last Page: 226
Page Count: 5
DOI: 10.2174/1871520611313020006
Price: $58

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