Multifunctionalized Microbubbles for Cancer Diagnosis and Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Multifunctionalized Microbubbles for Cancer Diagnosis and Therapy

Anti-Cancer Agents in Medicinal Chemistry, 13(3): 403-413.

Author(s): Hao Li, Jianhao Wang, Gang Huang, Ping Wang, Rongqin Zheng, Chao Zhang and Qing Jiang.

Affiliation: School of Engineering, Sun Yat-Sen University, Guangzhou 510006, P. R. China.


Microbubbles (MBs) are gas-filled hollow microparticles. Under the ultrasound field, the difference of acoustic characteristics between gas and plasma in the blood vessel will cause strong impedance mismatch and echogenicity to enhance ultrasonic grey scale imaging. The linear or nonlinear resonance of MB shell in the ultrasound field would lead to repeated expansion-contraction till destruction. In this case, the pre-loaded drug in the MB shell will be released in an accelerated manner triggered by the ultrasound at a probe–given site. Sonoporation effect of the cell membrane would also help increase the uptake of substances into cells. This paper is dedicated to review recent developments on MBs, especially multifunctionalized MBs, as a potential drug/gene delivery microdevices for both diagnosis and therapy of malignant tumors.


Microbubbles, Multifunctionalization, Cancer diagnosis, Cancer therapy, Contrast-enhanced ultrasonic imaging, Drug delivery system, Tumor-targeting, prostatectomy tissues, Phospholipid Microbubbles.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 13
Issue Number: 3
First Page: 403
Last Page: 413
Page Count: 11
DOI: 10.2174/1871520611313030004
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science