Cytoskeletal Alterations that Confer Resistance to Anti-tubulin Chemotherapeutics

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Cytoskeletal Alterations that Confer Resistance to Anti-tubulin Chemotherapeutics



Anti-Cancer Agents in Medicinal Chemistry, 13(1): 147-158.

Author(s): Arun Kanakkanthara, Paul H. Teesdale-Spittle and John H Miller.

Affiliation: Centre for Biodiscovery and School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand.

Abstract

Drugs that target microtubules are a successful class of anti-cancer agents that have been in clinical use for over two decades. Acquired resistance to these drugs, however, remains a serious problem. Microtubule alterations, such as tubulin mutations and altered β- tubulin isotype expression, are prominent factors in development of resistance. Changes in actin and intermediate filament proteins can also mediate sensitivity to microtubule-targeting drugs. This review focuses on the mechanisms by which alterations in cytoskeletal proteins lead to drug resistance. This information will be helpful for improving the targeting of microtubule toxins.

Keywords:

Actin, Cytoskeleton, Drug resistance, Intermediate filament, MDR, Microtubule, Microtubule-targeting drugs, C-terminal amino acids, Microfilaments, microtubule-destabilizers.



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Article Details

Volume: 13
Issue Number: 1
First Page: 147
Last Page: 158
Page Count: 12
DOI: 10.2174/1871520611307010147
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